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Principal Investigator in Developmental and Stem Cell Epigenetics


Toronto, ON, Canada
Open Date
Aug 14, 2018
Nov 1, 2018 at 11:59 PM Eastern Time




The Lunenfeld-Tanenbaum Research Institute (LTRI) of Sinai Health, a University of Toronto-affiliated biomedical research centre, is recruiting an emerging leader in the area of Developmental and Stem Cell Epigenetics. The appointment will be for a Principal Investigator (rank equivalent to Assistant Professor).

We seek applicants that will develop innovative, outstanding and independent programs in Developmental and Stem Cell Epigenetics.  Topic areas include, but are not limited to: germline biology and fertilization; early development and pluripotency; embryonic stem cells, lineage commitment; morphogenesis; organogenesis; adult stem cells; regeneration; targeted differentiation; regenerative medicine. Candidates are expected to approach these areas from the perspective of Epigenetics, broadly defined. This includes, but is not limited to: studies of DNA methylation; histone modifications; enhancer function; regulation of transcription; higher-order chromosome organization; nuclear dynamics; small and long RNA interactions with chromatin; environment-epigenome interactions; transgenerational inheritance. Experimental biologists using traditional model systems, be it vertebrates or invertebrates, as well as new model systems, are encouraged to apply.

The successful candidate will join the LTRI, whose faculty members are internationally renowned for their work in developmental and stem cell biology, epigenetics, signalling networks, cancer biology, structural biology, imaging, high throughput screening and proteomics. With numerous discoveries in basic and applied research in developmental biology, stem cell biology, pluripotency, epigenetics, systems biology, cancer, diabetes, genetic disorders and women’s and infants’ health, the LTRI is committed to excellence in health research and the training of young investigators.  The LTRI is the top research institute in Canada in high impact publications and funding per principal investigator. The LTRI provides a research-intensive environment with state-of-the-art and innovative core facilities that include the latest technology for short and long read deep-sequencing, proteomics, robotics, high-throughput screening and imaging that drive technology development. Sinai Health is also the home of The Centre for Phenogenomics, a state-of-the-art national facility for mouse models, and is a partner of Medicine by Design.

LTRI labs engage in productive collaborations within the Institute, Sinai Health, the larger University of Toronto community, and beyond. The University of Toronto has one of the most concentrated biomedical research communities in the world, including 9 academic hospital research institutes that are fully affiliated with the University. 


Investigators at the Lunenfeld-Tanenbaum Research Institute are appointed to independent positions equivalent to Assistant, Associate or Full Professor, depending on experience; preference for this opportunity will be given to individuals qualifying at the level of Assistant Professor.  Investigators will be cross-appointed to an appropriate research or clinical department at the University of Toronto.

Successful candidates will hold a PhD and/or MD degree, with postdoctoral experience and an established record of research accomplishment as demonstrated by outstanding publications, presentations at international conferences, awards and accolades, as well as strong endorsement by referees of high international standing.  The successful candidate will be expected to initiate and lead an innovative, independent, and externally funded, research program of the highest international calibre.

We offer competitive salary and start-up packages commensurate with experience and qualifications (illustrative range between $120,000 and $140,000).

An appropriately qualified individual may also be nominated for a Tier 2 Canada Research Chair.  Nominees should be within ten years of receiving their PhD. Applicants who are more than 10 years from having earned their highest degree (and where career breaks exist, such as maternity, parental or extended sick leave, clinical training, etc.) may have their eligibility for a Tier 2 chair assessed through the program’s Tier 2 justification process. For further information on these federally endowed chairs, open to all nationalities, including eligibility criteria, please consult the Canada Research Chairs website. For questions about the CRC nomination process at the University of Toronto and affiliated hospitals, contact Judith Chadwick, Assistant Vice-President, Research Services - crc@utoronto.ca.

Application Instructions

Applications should include:

- A one page structured summary that includes:  A) a brief education/training history; B) a summary of the applicant’s most important research contributions (up to five), and C) an abstract of the research plan
- A cover letter
- A research statement highlighting proposed research program (not exceeding 3 pages)
- A complete curriculum vitae
- Three reference letters

Applications should be submitted via the Interfolio website (http://apply.interfolio.com/53045) prior to November 1st, 2018.

Anticipated start is July 1st, 2019, or a date to be mutually agreed upon.

Applicants needing additional information can contact Dr. Miguel Ramalho-Santos at santos_search@lunenfeld.ca. E-mailed applications will not be accepted.

Application Process

This institution is using Interfolio's Faculty Search to conduct this search. Applicants to this position receive a free Dossier account and can send all application materials, including confidential letters of recommendation, free of charge.

Equal Employment Opportunity Statement


Sinai Health recognizes that scholars have varying career paths and that career interruptions due to personal circumstances can be part of an excellent academic record. Candidates are encouraged to explain any personal circumstances in order to allow for a fair assessment of their application. Search committee members have been instructed to give careful consideration to, and be sensitive to the impact of, career interruptions in their assessments.

Sinai Health is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, and members of sexual minority groups, and others who may contribute to the further diversification of ideas.


As part of your application, you will be asked to complete a brief Diversity Survey directly on the Interfolio site. This form is voluntary and any information directly related to you is confidential and cannot be accessed by the search committee. Results will be aggregated for institutional planning purposes as part of Sinai Health’s Equity, Diversity and Inclusion initiative.


In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases.

Sinai Health is a scent sensitive environment and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department. All qualified applicants are strongly encouraged to apply; however, in accordance with Canadian immigration requirements, Canadians and permanent residents will be given priority.