/ Researchers / investigators / wrana-jeffrey

  

Dr. Jeffrey Wrana

Lunenfeld-Tanenbaum
Research Institute
Mount Sinai Hospital
Joseph & Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario
M5G 1X5
 

Tel.: 416-586-4800 ext.2791

► Send Email

► Web of Science Researcher ID
F-8857-2013

► Publons ID
2638744

► Publications

  

Dr. Jeffrey Wrana

SENIOR INVESTIGATOR

Lunenfeld-Tanenbaum Senior Investigator Dr. Jeff Wrana is internationally recognized for his cancer research. While most current cancer investigations focus on specific disease pathways, Dr. Wrana believes cancer involves a complex network of pathways that work together to misregulate cells and cause disease. His research aims to expose the mechanisms involved in the development of these networks and to reveal new targets for treatments that would attack the entire disease network, not just individual hubs.

Dr. Wrana's research program involves the application of high-throughput, robotics-based technologies to interrogate biological systems on a genome-wide scale. He established the LTRI SMART high throughput biology facility that was amalgamated into the Network Biology Collaboration Centre in collaboration with Drs. Anne-Claude Gingras and Laurence Pelletier.

Dr. Wrana’s group is currently exploiting human patient specimens, animal models, and 3D organoid models, together with single cell technologies, to understand at the cellular and molecular level, the intimate link between the acquisition of stem cell phenotypes, tissue regeneration and the initiation and progression of cancer.

At a Glance

Studies the molecular basis underlying the intersection of early development, tissue regeneration and cancer

Discovered new ways by which cells communicate with each other

Holds the Mary Janigan Research Chair in Molecular Cancer Therapeutics

Inducted into the Royal Society of Canada in 2006

Received a Premier's Summit Award in 2010

Major Research Activities

Dr. Wrana's lab is primarily interested in defining the signalling networks that control tissue formation, how tissues regenerate after injury, and how these networks are aberrantly organized to drive cancer initiation and progression to metastatic disease. His current interests build on his discovery of the TGFbeta signalling pathway, the Smurf family of ubiquitin ligases that play key roles in cell polarity, and more recently on how these pathways are integrated with the Hippo tissue size control pathway. This work has revealed new mechanisms underlying cell fate determination and tissue regeneration in multiple models.

 

 

 

          
 LTRI
  About Us
   Senior Administration
   Research Committee
   Canada Research Chairs
   Technology Transfer
   Career Opportunities
  Researchers
   Investigators
    Dr. Irene L. Andrulis
    Dr. Rod Bremner
    Dr. Laurent Briollais
    Dr. Theodore J. Brown
    Dr. Shelley B. Bull
    Dr. Kieran Campbell
    Dr. Isabella Caniggia
    Dr. Robert F. Casper
    Dr. Graham L. Collingridge
    Dr. Sabine P. Cordes
    Dr. Joseph Culotti
    Dr. James Dennis
    Dr. Daniel J. Drucker
    Dr. Daniel Durocher
    Dr. Steven Gallinger
    Dr. Anne-Claude Gingras
    Dr. Pamela Goodwin
    Dr. Marc D. Grynpas
    Dr. Rayjean J. Hung
    Dr. Hartland W. Jackson
    Dr. Andrea Jurisicova
    Dr. Julia A. Knight
    Dr. Alexander G. Logan
    Dr. Stephen J. Lye
    Dr. Andras Nagy
    Dr. Michelle Nelson
    Dr. Kenichi Okamoto
    Dr. Laurence Pelletier
    Dr. Miguel Ramalho-Santos
    Dr. Frederick P. Roth
    Dr. Daniel Schramek
    Dr. Frank Sicheri
    Dr. Mark S. Silverberg
    Dr. Katherine Siminovitch
    Dr. Carolyn Steele Gray
    Dr. Ross Upshur
    Dr. Jim R. Woodgett
    Dr. Jeffrey Wrana
    Dr. Mei Zhen
    Dr. Bernard Zinman
   Clinician Scientists
    Dr. May Alarab
    Dr. Dominic Amato
    Dr. Amir Azarpazhooh
    Dr. Mrinalini Balki
    Dr. Chaim Bell
    Dr. Christine Brezden-Masley
    Dr. June C. Carroll
    Dr. Crystal Chan
    Dr. Martin C. Chang
    Dr. Kenneth Croitoru
    Dr. Ariel Dalfen
    Dr. Allan Detsky
    Dr. Brendan C. Dickson
    Dr. Rohan D. D’Souza
    Dr. Denice S. Feig
    Dr. Emer Finan
    Dr. John S. Floras
    Dr. Michael Fralick
    Dr. Shiphra R. Ginsburg
    Dr. Rebecca A. Gladdy
    Dr. Michael Goldberg
    Dr. Ellen Greenblatt
    Dr. Masoom A. Haider
    Dr. Jonathan J. Hunter
    Dr. Amna F. Husain
    Dr. Amish Jain
    Dr. Keith A. Jarvi
    Dr. Lianne P. Jeffs
    Dr. Jennie Johnstone
    Dr. Rita Kandel
    Dr. Edmond Kelly
    Dr. Erin D. Kennedy
    Dr. Edward C. Keystone
    Dr. James Khan
    Dr. John Kingdom
    Dr. Richard Kirsch
    Dr. Elena Kolomietz
    Dr. Caroline K. Kramer
    Dr. Stephen Lapinsky
    Dr. Shoo K. Lee
    Dr. Molyn Leszcz
    Dr. Susanna Mak
    Dr. Ann K. Malinowski
    Dr. Robert G. Maunder
    Dr. Taymaa May
    Dr. Allison McGeer
    Dr. Warren McIsaac
    Dr. Sangeeta Mehta
    Dr. Shikha Mittoo
    Dr. Ally Murji
    Dr. Kellie E. Murphy
    Dr. Geoffrey C. Nguyen
    Dr. Karel O'Brien
    Dr. Christian Pagnoux
    Dr. Claire Pain
    Dr. John Parker
    Dr. Bruce A. Perkins
    Dr. Allan Peterkin
    Dr. Aaron F. Pollett
    Dr. Paula Ravitz
    Dr. Albiruni A. Razak
    Dr. Ravi Retnakaran
    Dr. Robert H. Riddell
    Dr. Greg Ryan
    Dr. Joel Sadavoy
    Dr. Francisco J. Sanchez-Guerrero
    Dr. Amanda Selk
    Dr. Prakeshkumar Shah
    Dr. Vibhuti Shah
    Dr. Naveed Tahir Siddiqui
    Dr. Candice K. Silversides
    Dr. Daisy R. Singla
    Dr. Kim Tsoi
    Dr. Hillary A. Steinhart
    Dr. Carol Swallow
    Dr. Howard C. Tenenbaum
    Dr. Sharon L. Unger
    Dr. Chen Wang
    Dr. Virginia A. Wesson
    Dr. Lesley Wiesenfeld
    Dr. Rory Windrim
    Dr. Jay Wunder
    Dr. Alexandre Zlotta
   Staff Scientists
    Dr. Karen Colwill
    Dr. John Georgiou
    Dr. Gerald D. Gish
    Dr. Farzad Khalvati
    Dr. Colin Mckerlie
    Dr. Jinyi Zhang
   Associate Members / Scientists
    Dr. Gary D. Bader
    Dr. Bharati Bapat
    Dr. Marcus Bernardini
    Dr. Lisa D. Burry
    Dr. George S. Charames
    Dr. Mary Chiu
    Dr. Eleftherios P. Diamandis
    Dr. Sarah Ferguson
    Dr. Michael Glogauer
    Dr. Jack M. Goodman
    Dr. Tae Hart
    Dr. Johannes Keunen
    Dr. Sarina Isenberg
    Dr. Jordan Lerner-Ellis
    Dr. Zhong-Cheng Luo
    Dr. Stephen G. Matthews
    Dr. John R. McLaughlin
    Dr. Helen McNeill
    Dr. Massieh Moayedi
    Dr. Abdul Noor
    Dr. Ian M. Rogers
    Dr. Mike Tyers
    Dr. Pete Wegier
   Physician Directory
  Research Resources
   Our Research
   Expertise
  Training Centre
  News
   Spotlight
    Innovations in prostate cancer research during moustache season and beyond
    New genetic discoveries offer hope to IBD patients
    Diabetes: disease of the 21st century will affect approximately 500 million by 2030
    What does a worm’s nervous system tell us about disorders like Huntington’s Disease?
    The Year in Review: 2012 Highlights from the Samuel Lunenfeld Research Institute
    Millennials Help Scientists Transform Breast Cancer Research
    How Research Impacts Your Health
    2013 International Symposium: Frontiers in Diabetes Research
    $35 Million Gift from Larry and Judy Tanenbaum Launches Fundraising Drive for Endowment to Support Medical Research
    Director warns why we shouldn't neglect basic science in favour of applied science
    The anatomy of a major discovery
    Unravelling the mysteries of complex brain disorders
    LTRI Q&A: How do we predict breast cancer risk more effectively?
    Michal Zimmermann and his efforts to improve cancer drug efficacy
    Dheva Setiaputra
    Salomé Adam
   Discovery Corner
    Not your typical March Break: the life of an intern at the LTRI
  COVID-19
  Aside
   Slides relating to the recommendations of CANADA'S FUNDAMENTAL SCIENCE REVIEW