/ Researchers / associate-members / rogers-ian


Dr. Ian M. Rogers

Lunenfeld- Tanenbaum
Research Institute
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Complex
600 University Avenue
Toronto, Ontario
M5G 1X5

Tel.: 416-586-4800 ext.4122

► Send Email

► insception.com

► Google Scholar

► ResearchGate

► Web of Science Researcher ID


► Publons ID

► Publications


Dr. Ian M. Rogers


Dr. Rogers’ lab is focused on developing three dimensional tissue culture systems to improve stem cell studies. By combining stem cells with decellularized organs, his aim is to advance studies on stem cell differentiation, cell-cell signaling and understanding the complex three-dimensional organization of cells into functional organs and tissues.

His research focuses on the following areas:

Cell therapies

Blood cells and mesenchymal cells from umbilical cord blood or tissue are a suitable source of cells for regenerative medicine to treat peripheral vascular disease (PVD) and non-healing skin wounds. For the treatment of PVD and non-healing wounds the ability of transplanted blood and mesenchymal cells to induce tissue repair mechanisms in endogenous cells is being investigated. The lab has demonstrated that CD34+ blood cells or mesenchymal stromal cells from umbilical cord tissue or blood can be isolated, grown in vitro, during which they develop the ability to secrete factors that support cell survival, blood vessel growth and cell migration important for tissue repair.



The goal of this project is the development of a tissue culture system that will improve studies in the area of reproduction. In collaboration with Dr. Greenblatt, we have adapted our decellularized organ culture system to the ovary. Our goal is to develop in vitro methods for the maturation of prepubescent follicles to oocytes that can be successfully fertilized, from cryopreserved ovarian tissue from young patients undergoing chemotherapy and radiation treatment. We are using rabbit ovaries to carry out the initial studies that include empirically determining the appropriate decellularization regimen and the best method to repopulate the acellular ovary with new cells in order to provide the proper milieu for oocyte development.



Aging in attributed to the limitation of the half-life of our cells coupled to the diminishing ability of the tissue niche to support tissue repair over time. The former is a limitation inherited in our mature somatic cells while the latter is a limitation of our stem/progenitor cells and their niche. Since aging is the eventual exhaustion of our body’s ability to regenerate we can offset the breakdown of our tissues by replenishing the tissue stem cells, the stem cell niche, the engraftment of mature somatic cells or all three. Although not all diseases are due to aging, the need for stem cell or mature cell replacement is required for both. The Rogers lab, by utilizing different stem cells, differentiation protocols and disease models has demonstrated that stem cells or mature cells can be used separately or in combination to regenerate tissue in diseased and aged mice. Because of the similarities in embryo development, tissue repair and aging, appropriate disease or tissue damage models can be used to test therapies aimed and reducing the effects of aging on our organs.


Kidney Disease

The Rogers’ lab is also focused on studying diabetic nephropathy. This project allows for investigating the role of stem cells and their niche. By using decellularized kidney from healthy and diabetic mice (or humans) coupled with kidney progenitor and mature cells from healthy and diabetic sources, we can determine if diabetes is affecting the niche or the progenitor cells.


Somatic Cell Reprogramming

Harnessing the reprogramming mechanism to generate safe, clinically relevant stem cells for therapy is an important goal. As part of an international research consortium lead by Dr. Andras Nagy a thorough examination of the changes in the proteome, secretome, genome and transcriptome that occurs during reprogramming was carried out. This effort has resulted in a large public data-base that can be found at www.stemformatics.com. Building on this work my main aim is to continue to investigate whether reprogramming occurs in an orderly predictable manner and if there are stable intermediates that have developed the ability of proliferation and de-differentiation without completely losing their somatic cell properties. It is expected these stable intermediates are safer that fully reprogrammed cells as they do not form teratomas.

At a Glance

Dr. Rogers was involved with the establishment of Canada's first, and largest, cord blood bank, first located at Mount Sinai Hospital and now managed by Insception Lifebank (www.insception.com).

Dr. Rogers studies hematopoietic stem cells and their use in regenerative medicine.

His research focuses on stem cell therapies for peripheral vascular disease, non-healing diabetic skin wounds and kidney disease.

He is developing tissue culture systems using decellularized organs such as kidney, ovary and pancreas

His lab is also investigating new types of therapeutic cells generated through somatic cell reprogramming.

Major Research Activities

One of the major goals of the lab is the development of better in vitro tissue culture systems that can be used to replace expensive animal models for the study of stem cells. The lab is developing tissue culture systems using decellularized ovary, kidney and pancreas. Current tissue culture techniques do not allow for the complex cell-cell or important cell-extracellular matrix interactions required for proper tissue development. By using decellularized organs it is easier to recapitulate the natural three-dimensional organization of tissue and organs.

Furthermore, the Rogers lab has demonstrated that the extracellular matrix (ECM) left behind after the cells are removed retains bio-active proteins capable of directing cell migration, proliferation and differentiation. The ability of the adult ECM to direct stem cell differentiation is not surprising since tissue repair and regeneration mechanisms and factors are similar to those used in embryogenesis and organogenesis.




  About Us
   Senior Administration
   Research Committee
   Canada Research Continuity Emergency Fund
    Funding Opportunities
     CRCEF - Stage 3
   Canada Research Chairs
   Technology Transfer
   Career Opportunities
    Dr. Irene L. Andrulis
    Dr. Rod Bremner
    Dr. Laurent Briollais
    Dr. Theodore J. Brown
    Dr. Shelley B. Bull
    Dr. Kieran Campbell
    Dr. Isabella Caniggia
    Dr. Robert F. Casper
    Dr. Graham L. Collingridge
    Dr. Sabine P. Cordes
    Dr. Joseph Culotti
    Dr. James Dennis
    Dr. Daniel J. Drucker
    Dr. Daniel Durocher
    Dr. Steven Gallinger
    Dr. Anne-Claude Gingras
    Dr. Pamela Goodwin
    Dr. Marc D. Grynpas
    Dr. Rayjean J. Hung
    Dr. Hartland W. Jackson
    Dr. Andrea Jurisicova
    Dr. Julia A. Knight
    Dr. Alexander G. Logan
    Dr. Stephen J. Lye
    Dr. Andras Nagy
    Dr. Michelle Nelson
    Dr. Kenichi Okamoto
    Dr. Laurence Pelletier
    Dr. Miguel Ramalho-Santos
    Dr. Frederick P. Roth
    Dr. Daniel Schramek
    Dr. Frank Sicheri
    Dr. Mark S. Silverberg
    Dr. Katherine Siminovitch
    Dr. Carolyn Steele Gray
    Dr. Ross Upshur
    Dr. Jim R. Woodgett
    Dr. Jeffrey Wrana
    Dr. Mei Zhen
    Dr. Bernard Zinman
   Clinician Scientists
    Dr. May Alarab
    Dr. Dominic Amato
    Dr. Amir Azarpazhooh
    Dr. Mrinalini Balki
    Dr. Chaim Bell
    Dr. Christine Brezden-Masley
    Dr. June C. Carroll
    Dr. Crystal Chan
    Dr. Kenneth Croitoru
    Dr. Ariel Dalfen
    Dr. Allan Detsky
    Dr. Brendan C. Dickson
    Dr. Rohan D. D’Souza
    Dr. Denice S. Feig
    Dr. Emer Finan
    Dr. John S. Floras
    Dr. Michael Fralick
    Dr. Shiphra R. Ginsburg
    Dr. Rebecca A. Gladdy
    Dr. Michael Goldberg
    Dr. Ellen Greenblatt
    Dr. Masoom A. Haider
    Dr. Jonathan J. Hunter
    Dr. Amna F. Husain
    Dr. Amish Jain
    Dr. Keith A. Jarvi
    Dr. Lianne P. Jeffs
    Dr. Jennie Johnstone
    Dr. Rita Kandel
    Dr. Edmond Kelly
    Dr. Erin D. Kennedy
    Dr. Edward C. Keystone
    Dr. James Khan
    Dr. John Kingdom
    Dr. Richard Kirsch
    Dr. Elena Kolomietz
    Dr. Caroline K. Kramer
    Dr. Stephen Lapinsky
    Dr. Shoo K. Lee
    Dr. Molyn Leszcz
    Dr. Susanna Mak
    Dr. Ann K. Malinowski
    Dr. Robert G. Maunder
    Dr. Taymaa May
    Dr. Allison McGeer
    Dr. Warren McIsaac
    Dr. Sangeeta Mehta
    Dr. Shikha Mittoo
    Dr. Ally Murji
    Dr. Kellie E. Murphy
    Dr. Geoffrey C. Nguyen
    Dr. Karel O'Brien
    Dr. Christian Pagnoux
    Dr. Claire Pain
    Dr. John Parker
    Dr. Bruce A. Perkins
    Dr. Allan Peterkin
    Dr. Aaron F. Pollett
    Dr. Paula Ravitz
    Dr. Albiruni A. Razak
    Dr. Ravi Retnakaran
    Dr. Robert H. Riddell
    Dr. Greg Ryan
    Dr. Joel Sadavoy
    Dr. Francisco J. Sanchez-Guerrero
    Dr. Amanda Selk
    Dr. Prakeshkumar Shah
    Dr. Vibhuti Shah
    Dr. Naveed Tahir Siddiqui
    Dr. Candice K. Silversides
    Dr. Daisy R. Singla
    Dr. Kim Tsoi
    Dr. Hillary A. Steinhart
    Dr. Carol Swallow
    Dr. Howard C. Tenenbaum
    Dr. Sharon L. Unger
    Dr. Chen Wang
    Dr. Alanna Weisman
    Dr. Virginia A. Wesson
    Dr. Lesley Wiesenfeld
    Dr. Rory Windrim
    Dr. Jay Wunder
    Dr. Alexandre Zlotta
   Staff Scientists
    Dr. Karen Colwill
    Dr. John Georgiou
    Dr. Colin Mckerlie
    Dr. Jinyi Zhang
   Associate Members / Scientists
    Dr. Gary D. Bader
    Dr. Bharati Bapat
    Dr. Marcus Bernardini
    Dr. Lisa D. Burry
    Dr. George S. Charames
    Dr. Mary Chiu
    Dr. Eleftherios P. Diamandis
    Dr. Sarah Ferguson
    Dr. Michael Glogauer
    Dr. Jack M. Goodman
    Dr. Tae Hart
    Dr. Johannes Keunen
    Dr. Jordan Lerner-Ellis
    Dr. Zhong-Cheng Luo
    Dr. Stephen G. Matthews
    Dr. John R. McLaughlin
    Dr. Helen McNeill
    Dr. Massieh Moayedi
    Dr. Abdul Noor
    Dr. Ian M. Rogers
    Dr. Mike Tyers
   Physician Directory
   Our Research
  Trainee Centre
   Summer Research Program
    Innovations in prostate cancer research during moustache season and beyond
    New genetic discoveries offer hope to IBD patients
    Diabetes: disease of the 21st century will affect approximately 500 million by 2030
    What does a worm’s nervous system tell us about disorders like Huntington’s Disease?
    The Year in Review: 2012 Highlights from the Samuel Lunenfeld Research Institute
    Millennials Help Scientists Transform Breast Cancer Research
    How Research Impacts Your Health
    2013 International Symposium: Frontiers in Diabetes Research
    $35 Million Gift from Larry and Judy Tanenbaum Launches Fundraising Drive for Endowment to Support Medical Research
    Director warns why we shouldn't neglect basic science in favour of applied science
    The anatomy of a major discovery
    Unravelling the mysteries of complex brain disorders
    LTRI Q&A: How do we predict breast cancer risk more effectively?
    Michal Zimmermann and his efforts to improve cancer drug efficacy
    Dheva Setiaputra
    Salomé Adam
   Discovery Corner
    Not your typical March Break: the life of an intern at the LTRI
   Slides relating to the recommendations of CANADA'S FUNDAMENTAL SCIENCE REVIEW