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Dr. Steven Gallinger

Research Institute
Mount Sinai Hospital
Joseph & Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario
M5G 1X5

Tel.: 416-586-4800 ext.8550

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Dr. Steven Gallinger


Dr. Steven Gallinger is a clinician-scientist, and surgical oncologist with an interest in gastrointestinal cancer genetics. As a Senior Investigator at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Dr. Gallinger studies the genetics of both inherited and acquired molecular aspects of colorectal and pancreatic cancer. 

Dr. Gallinger's lab was one of the first to demonstrate that a gene mutation known as K-ras is present in early colorectal cancer cells. Dr. Gallinger and his team have also determined the sequence of molecular genetic events in Familial Adenomatous Polyposis. This has placed his lab at the forefront in the field of GI cancer genetics, both in Canada and internationally.

Dr. Gallinger also contributed to the international ARCTIC Genome Project that identified a gene variation associated with colorectal cancer--the first genetic predictor associated with common forms of colorectal cancer and a tool for future screening methods. Recently, his group also played a key role in an international team that identified four new genes for colorectal cancer. The study examined 38,710 genetic markers in 13,315 individuals from four countries. A total of 10 genes are now linked to colorectal cancer, and together these genes could predict up to a six-fold increase in the lifetime risk of developing this common disease. In addition, Dr. Gallinger is identifying and characterizing the early molecular events during the development of pancreatic cancer.

At a Glance

Dr. Steven Gallinger is a GI surgeon and has developed genetic tests used by the province to predict response to chemotherapy treatments

Discovered new genes related to colorectal cancer

Developed a familial colon and pancreatic cancer tumour bank which he and other researchers are using to identify new genes that predispose to these diseases

Previous holder of the Oakdale Golf & Country Club / George Knudson Research Chair in Gastrointestinal Cancer

Major Research Activities

Dr. Gallinger's laboratory is studying both inherited and acquired molecular aspects of colorectal cancer and pancreatic cancer. His team is using a number of different approaches including large-scale population-based studies, gene identification studies, and studies of tumours in mouse models. Dr. Gallinger is currently undertaking identification and characterization of the early molecular events during the development of pancreatic cancer.