The Lunenfeld-Tanenbaum Research Institute
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Dr. Jim R. Woodgett
Home Researchers Dr. Jim R. Woodgett

Dr. Jim R. Woodgett

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Research Institute
Mount Sinai Hospital
Joseph & Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario M5G 1X5


Tel: 416-586-4800 ext.8811
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Dr. Jim Woodgett 

In his dual roles as Investigator and Director of Research of the Lunenfeld-Tanenbaum Research Institute, Dr. Jim Woodgett applies his visionary approach to research into the manipulation of cell processes to treat certain cancers, diabetes and neurodegenerative conditions, and to ensuring that discoveries made by the world-renowned Institute are applied to patient care.

Dr. Woodgett is interested in the causes and treatment of breast cancer, colorectal cancer, diabetes, Alzheimer Disease and bipolar disorder. What links this apparently broad range of diseases is their common basis in disruption of the lines of communication within the cells, or the signalling pathways. By studying the ways in which components of these pathways are mutated and transformed by disease, Dr. Woodgett can identify new and more effective therapeutic targets. Study of the WNT pathway, which contains a number of genes which account for about 90% of human colon cancer, is a particular area of interest.

Wnt signalling depends on a number of proteins that play essential roles in other signalling pathways raising the question of signal selectivity. The laboratory is using proteomics and proximity assays in cells to understand how signalling systems are effectively insulated from each other, wth implications for enhanced drug targeting specificity.





At a Glance

  • Director of Research for the Lunenfeld-Tanenbaum; also holds the Koffler Directorship for the Lunenfeld-Tanenbaum Research Institute
  • Researches the manipulation of cell processes to treat certain cancers, diabetes and neurodegenerative conditions
  • Focuses on regulatory proteins called kinases -- the master switches in cells that control responses to the environment
  • Harvests adult stem cells — which hold great promise for the treatment and cure of life-threatening illnesses


Major Research Activities

Dr. Woodgett's group is studying the molecular mechanisms by which the Wnt and PI3K pathways are dysregulated in human cancers such as breast and colon cancer. His laboratory is also studying the roles of signaling pathways in type-2 diabetes and stem cell fate determination and has a long-standing interest in genomics applications such as DNA microarrays and protein arrays.


Recent Publications


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