The Lunenfeld-Tanenbaum Research Institute
Donate Now - Mount Sinai Hospital Foundation of Toronto Lunenfeld QR code
Personal tools
Dr. Daniel Schramek
Home Researchers Dr. Daniel Schramek

Dr. Daniel Schramek

daniel schramek.jpg

 

Lunenfeld- Tanenbaum
Research Institute
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Complex
600 University Ave, Room 1080
Toronto Canada, M5G 1X5

► Send Email
► Lab Website

 

 

Dr. Daniel Schramek
INVESTIGATOR

Dr. Daniel Schramek joined the LTRI in April 2015. He trained in Europe, Australia and the US, receiving a BA and an MSc in Molecular Biology, a PhD in Genetics and an Executive MSc in Technology Management. For the last four years, he was a postdoctoral fellow and Emerald Foundation Young Investigator at the Rockefeller University (NY). 

Dr. Schramek’s vision is to leverage functional genomics to make major advances in treating human cancers in a personalized and highly specific manner by analyzing the exact molecular underpinnings why a tumour develops. A tumour accumulates hundreds of gene mutations but which of those mutation or combination of mutations initiate tumour development and controls metastases? Dr. Schramek has developed a new technique that can weed out the random genetic bystander mutations and identify the ones that are critical for cancer as those have diagnostic and therapeutic implications. 
 
His new technique takes advantage of RNA interference (RNAi), a natural process whereby short RNA pieces interfere and turn off the function of specific genes. These RNAi molecules are first packaged into highly concentrated viruses and then injected into the embryonic sac of a developing mouse embryo using ultrasound to guide the injection needle. Using this method Dr. Schramek’s team can assess up to 300 potential cancer genes in an adult mouse in as little as five weeks.
 
Previously, Dr. Schramek focused his research efforts on Head & Neck Squamous Cell Carcinomas (HNSCCs), one of the most common and deadliest cancers, and could identify several new tumour suppressor genes. He also designed a new therapeutic strategy specifically for patients, who carry mutations in one of those new genes. Now, he is working to elucidate the driving mutations in breast and bladder cancer and will also use his unique technique to find not only genes, which cause cancer but also the genes, which are required for tumour growth – the quest for a tumour’s Achilles’ heel.
 
His breakthrough technologies have been recognized with professional awards such as the Regeneron Innovation Award and the Alois Sonnleitner Prize for Outstanding Cancer Research by the Austrian Academy. He was also named Anna D. Barker Fellow in Basic Cancer Research by the AACR and Nobel Prize Laureate, Elizabeth Blackburn.
 
 

 

At a Glance

  • Dr. Daniel Schramek joined the LTRI as an Investigator in April 2015
  • His research focuses on leveraging functional genomics to make major advances in treating human cancers in a personalized and highly specific manner by identifying and characterizing why a tumour develops.
  • One of his biggest contributions to this field so far has been to elucidate the molecular link between synthetic hormones, stem cells and breast cancer.
     

 

Major Research Activities

His work focuses on mutations and genes responsible for tumorigenesis and metastasis, and aims to further improve current cancer therapies and treatment for HNSCC patients.
His goal is to also discover the driving mutations in breast and bladder cancer and will use the unique direct in vivo RNAi technique that he has helped to create, in order to find all the genes required for tumor growth – the quest for a tumour’s Archille’s heel.  In addition to elucidating the basic molecular and cellular mechanisms involved in tumorigenesis, he will maintain a clinical perspective of research in the lab by collaborating with clinicians such as Dr. Alex Zlotta, uro-oncologist at Mount Sinai Hospital. 

 

Recent Publications

 

 

Document Actions
Ontario Health Study Faculty of Medicine, University of Toronto. mitacs honorary partner

 

 
plone
       
 
   
spinner
Facebook popup Youtube popup Twitter popup RSS popup