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Soft tissue sarcomas (STS) are a diverse group of tumors derived
from connective tissue (muscle, fat and bone).
Current treatment of STS is limited primarily to surgical procedures
(e.g., removing the sarcoma), with selective use of radiation therapy
and the use of conventional chemotherapy in some subtypes of the
disease. Unfortunately, these treatment options are limited in their
effectiveness and more than 50 per cent of STS patients succumb to this
Researchers have recognized that there is an urgent need to develop
subtype-specific molecularly targeted therapeutics that can provide new
treatment options unique to each histologic type of sarcoma.
Our program has focused on developing novel therapies for:
rhabdomyosarcoma, a tumor mainly found in children and adult sarcomas
including leiomyosarcoma and undifferentiated pleomorphic
to the Department of Surgery at Mount Sinai Hospital
oncologist specializing in sarcoma
of the GI Sarcoma Clinical Research Program
of the Toronto International Sarcoma Symposium
main goals of our Translational Sarcoma Research Program
identify targeted agents through the use of high-throughput screens of
sarcoma cell lines in the SMART facility at the Lunenfeld-Tanenbaum
Research Institute with further validation in the Gladdy
develop faithful and genetically flexible mouse models of sarcoma as a
tool to functionally validate genomic data and for pre-clinical drug
readily translate laboratory findings via clinical trials to sarcoma
patients in Ontario.
- Hamilton TD, Cannell AJ, Kim M, Catton CN, Blackstein ME, Dickson
BC, Gladdy RA, Swallow CJ. Results of Resection for Recurrent or
Residual Retroperitoneal Sarcoma After Failed Primary Treatment. Ann
Surg Oncol. 2017 Jan 1;24(1):211-218.
- Gladdy RA, Gupta A, Catton CN. Retroperitoneal Sarcoma:
Fact, Opinion, and Controversy. Surg Oncol Clin N Am. 2016 Oct
- Burtenshaw SM, Cannell AJ, McAlister ED, Siddique S, Kandel R,
Blackstein ME, Swallow CJ, Gladdy RA. Toward Observation as
First-line Management in Abdominal Desmoid Tumors. Ann Surg Oncol. 2016
Jul 1;23(7):2212-9. See Comment, Editorial by van Broekhoven DL,
Grunhagen DJ, Verhoef C, Ann Surg Oncol.
- Babichev Y, Kabaroff L, Datti A, Uehling D, Isaac M, Al-Awar R,
Prakesch M, Sun RX, Boutros PC, Venier R, Dickson BC, Gladdy RA.
PI3K/AKT/mTOR inhibition in combination with doxorubicin is an
effective therapy for leiomyosarcoma. J Transl Med. 2016 Mar
- Wong P, Hui A, Su J, Yue S, Haibe-Kains B, Gokgoz N, Xu W, Bruce J,
Williams J, Catton C, Wunder JS, Andrulis IL, Gladdy R, Dickson
B, O’Sullivan B, Liu FF. Prognostic microRNAs modulate the RHO adhesion
pathway: A potential therapeutic target in undifferentiated pleomorphic
sarcomas. Oncotarget. 2015 Nov 17;6(36):39127-39139.
- McKinnon T, Venier R, Dickson BC, Kabaroff L, Alkema M, Chen L,
Shern JF, Yohe ME, Khan J, Gladdy RA. Kras activation in
p53-deficient myoblasts results in high-grade sarcoma formation with
impaired myogenic differentiation. Oncotarget. 2015 Jun
- Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo
L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG.
MicroRNA-182 drives metastasis of primary sarcomas by targeting
multiple genes. J Clin Invest. 2014 Oct 1;124(10):4305-19.
- Fiore M, Coppola S, Cannell AJ, Colombo C, Bertagnolli MM, George
S, Le Cesne A, Gladdy RA, Casali PG, Swallow CJ, Gronchi A,
Bonvalot S, Raut CP. Desmoid-type fibromatosis and pregnancy: a
multi-institutional analysis of recurrence and obstetric risk. Ann
Surg. 2014 May;259(5):973-8.
- Kabaroff L, Gupta A, Menezes S, Babichev Y, Kandel RC, Swallow CJ,
Dickson BC, Gladdy RA. Development of genetically flexible mouse
models of sarcoma using RCAS-TVA mediated gene delivery. PLoS One. 2014