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Dr. Anne-Claude Gingras
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Dr. Anne-Claude Gingras 
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Dr. Anne-Claude Gingras is focused on the cellular mechanisms involved in cancer and in resistance to cancer drugs. She is a recognized authority in the field of proteomics – the study of a full set of proteins in a particular cell – and in the cellular pathways that control cell growth.

Using the latest technology available to explore cell function, Dr. Gingras seeks new insights into why and how cells grow and proliferate. In particular she is focused on molecules involved in cell growth and proliferation, which present attractive targets for cancer therapy. Her research is aimed at generating new information on how signals are relayed within cells with the goal of moderating the uncontrolled cell division that characterizes tumors.

In order to conduct her research, Dr. Gingras uses a state-of-the-art mass spectrometer, a device that helps researchers analyze cells at the molecular level. As part of her research program, she is working to develop specialized mass spectrometry tools that will help other researchers better analyze basic cellular processes involved in health and disease.

 
Samuel Lunenfeld Research Institute
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario M5G 1X5
t 416-586-4800 ext.5027
f 416-586-5993
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May 21, 2009 03:35 PM

    
  

At a Glance

  • Seeks new insights into why and how cells grow and proliferate – or turn “on” and “off”
  • Holds the Canada Research Chair in Functional Proteomics; the Lea Reichmann Research Chair in Cancer Proteomics 
  • Received a prestigious Early Researcher Award from the Ontario Ministry of Research and Innovation in 2007
  • Uses mass spectrometry to study protein-protein interactions that play a role in the development of cancer, drug resistance and innate immunity
  • Has found a link between a protein complex and human resistance to the cancer drug cisplatin

 

 

Major Research Activities

Cells respond to signals (e.g. from hormones or stresses) by initiating cascades of phosphorylation events: kinases add phosphate groups onto proteins, while phosphatases remove these phosphates. Deregulation of the phosphorylation/
dephosphorylation balance often results in disease, including cancer and diabetes. Using an array of cell biology and proteomics approaches, Dr. Gingras aims to better understand how phosphatases are regulated, and to decipher the impact of each phosphatase on cell growth and proliferation.

 

 

Recent Publications

 

 

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