Dr. Steven Gallinger — The Samuel Lunenfeld Research Institute

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Dr. Steven Gallinger

SENIOR INVESTIGATOR

Dr. Steven Gallinger is a clinician-scientist, and surgical oncologist with an interest in gastrointestinal cancer genetics. As a senior investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Dr. Gallinger studies the genetics of both inherited and acquired molecular aspects of colorectal and pancreatic cancer.

Dr. Gallinger’s lab was one of the first to demonstrate that a gene mutation known as K-ras is present in early colorectal cancer cells. Dr. Gallinger and his team have also determined the sequence of molecular genetic events during upper gastro-intestinal in Familial Adenomatous Polyposis. This has placed his lab at the forefront in the field of GI cancer genetics, both in Canada and internationally.

Dr. Gallinger also contributed to the international ARCTIC Genome Project that identified a gene variation associated with colorectal cancer--the first genetic predictor associated with common forms of colorectal cancer and a tool for future screening methods. Recently, his group also played a key role in an international team that identified four new genes for colorectal cancer. The study examined 38,710 genetic markers in 13,315 individuals from four countries. A total of 10 genes are now linked to colorectal cancer, and together these genes could predict up to a six-fold increase in the lifetime risk of developing this common disease. In addition, Dr. Gallinger is identifying and characterizing the early molecular events during the development of pancreatic cancer.

Samuel Lunenfeld
Research Institute
Mount Sinai Hospital
Joseph & Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario M5G 1X5

Tel: 416-586-4800 ext.8550
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Jul 15, 2009 04:10 PM

At a Glance

Dr. Steven Gallinger is a GI surgeon and has developed genetic tests used by the province to predict response to chemotherapy treatments
Discovered new genes related to colorectal cancer
Developed a familial colon and pancreatic cancer tumour bank which he and other researchers are using to identify new genes that predispose to these diseases
Holds the Oakdale Golf & Country Club / George Knudson Research Chair in Gastrointestinal Cancer

Major Research Activities

Dr. Gallinger’s laboratory is studying both inherited and acquired molecular aspects of colorectal cancer and pancreatic cancer. His team is using a number of different approaches including large-scale population-based studies, gene identification studies, and studies of tumours in mouse models. Dr. Gallinger is currently undertaking identification and characterization of the early molecular events during the development of pancreatic cancer.

Recent Publications

Analysis of the Gene Coding for the BRCA2-Interacting Protein PALB2 in Familial and Sporadic Pancreatic Cancer. Tischkowitz M, Sabbaghian N, Hamel N, Rosner C, Taherian N, Srivastava A, Foulkes WD, Tischkowitz M, Sabbaghian N, Rosner C, Taherian N, Srivastava A, Foulkes WD, Hamel N, Taherian N, Foulkes WD, Borgida A, Holter S, Rothenmund H, Gallinger S, Ghadirian P, Gallinger S.Gastroenterology. 2009 Jul 24. [Epub ahead of print] No abstract available. PMID: 19635604 [PubMed - as supplied by publisher]

Related Articles
Development of Quality Indicators of Care for Patients Undergoing Hepatic Resection for Metastatic Colorectal Cancer Using a Delphi Process. Dixon E, Armstrong C, Maddern G, Sutherland F, Hemming A, Wei A, Sherman M, Moore M, McKay A, Urbach D, Labrie M, Gordon L, Barkun J, Lynn Quan M, Dowden S, Bigam D, Gallinger S. J Surg Res. 2009 May 12. [Epub ahead of print] PMID: 19592015 [PubMed - as supplied by publisher]

Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study.
Cleary SP, Cotterchio M, Jenkins MA, Kim H, Bristow R, Green R, Haile R, Hopper JL, LeMarchand L, Lindor N, Parfrey P, Potter J, Younghusband B, Gallinger S. Gastroenterology. 2009 Apr;136(4):1251-60. Epub 2008 Dec 27.

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Houlston RS, Webb E, Broderick P, Pittman AM, Di Bernardo MC, Lubbe S, Chandler I, Vijayakrishnan J, Sullivan K, Penegar S; Colorectal Cancer Association Study Consortium, Carvajal-Carmona L, Howarth K, Jaeger E, Spain SL, Walther A, Barclay E, Martin L, Gorman M, Domingo E, Teixeira AS; CoRGI Consortium, Kerr D, Cazier JB, Niittymäki I, Tuupanen S, Karhu A, Aaltonen LA, Tomlinson IP, Farrington SM, Tenesa A, Prendergast JG, Barnetson RA, Cetnarskyj R, Porteous ME, Pharoah PD, Koessler T, Hampe J, Buch S, Schafmayer C, Tepel J, Schreiber S, Völzke H, Chang-Claude J, Hoffmeister M, Brenner H, Zanke BW, Montpetit A, Hudson TJ, Gallinger S; International Colorectal Cancer Genetic Association Consortium, Campbell H, Dunlop MG.
Nat Genet. 2008 Dec;40(12):1426-35. Epub 2008 Nov 16. PMID: 19011631 [PubMed - indexed for MEDLINE]

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