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Dr. Eleftherios P.
Diamandis
ASSOCIATE
MEMBER
Dr. Eleftherios P. Diamandis is Section Head of Clinical Biochemistry,
Department of Pathology and Laboratory Medicine Mount Sinai Hospital,
Professor and Head, Division of Clinical Biochemistry, Department of
Laboratory Medicine and Pathobiology, University of Toronto and
Biochemist-in-Chief, Laboratory Medicine Program, University Health
Network, Toronto Ontario.
Research
in Dr. Diamandis’ lab focuses on four major
areas:
A)
Discovery and validation of novel biomarkers for diagnosis, prognosis
and monitoring of cancer and other diseases. Dr. Diamandis is using
proteomics and mass spectrometry techniques to achieve these
goals
B)
Study of the physiology and pathobiology of kallikreins and
kallikrein-related peptidases. Kallikreins are a group of 15 serine
proteases which participate in many biological processes, including
cell signaling, tissue remodeling, wound healing, skin desquamation,
cognition, etc. In cancer, kallikreins participate in invasion and
metastasis. The Diamandis laboratory was the first to clone the genes
for several members of this family and has constructed the first map of
all 15 genes on chromosome 19q.13.4.
C)
Examination of the therapeutic potential of cardiac glycosides.
Recently, the Diamandis laboratory identified anticarcinogenic
activities of cardial glycosides and especially, their synergistic
effects with other drugs. This work is mainly carried out by
high-throughput screening of large chemical
libraries.
D) The
Diamandis laboratory is investigating novel ways for prenatal diagnosis
of Down Syndrome and other fetal abnormalities by using proteomics and
mass spectrometry. Recently, our laboratory was the first to delineate
the proteome of human amniotic fluid.
Dr.
Diamandis is a member of many International and Professional
Associations including the American Association for Clinical Chemistry,
the Canadian Society of Clinical Chemists, the American Association for
the Advancement of Science, etc. He is also a member of the Royal
Society of Canada and corresponding member of the Academy of Athens,
Greece. He is, or was, on the Editorial Board of 30 Journals including
Clinical Chemistry, Cancer Research, British Journal of Cancer,
International Journal of Cancer and BMC Medicine. He won many awards
from National and International Organizations.
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