Dr. Joseph Culotti

INVESTIGATOR

Dr. Joseph Culotti conducts basic research to understand the development and function of the nervous system. In particular, he looks for genes that regulate and guidance of the growth of neurons. His research has significant implications for the development of new treatments for spinal cord injury. By understanding the mechanisms involved in the development of the spinal cord, we may ultimately be able to re-activate them, enabling severed neurons to reconnect and repair an injured cord.

In order to study the nervous system, Dr. Culotti uses a small roundworm called C. elegans, which he describes as “a simplified spinal cord.” Its simplicity makes C. elegans an ideal research model, and Dr. Culotti has discovered startling similarities between the growth of the worm’s neurons and those in the human spinal cord. What he learns from the worm therefore has great relevance to our understanding of the development and regeneration of the human nervous system.

Working in collaboration with researchers at Johns Hopkins University, Dr. Culotti has found that similar molecules guide the growing neurons along the same axis in the developing human spinal cord as they do in the humble C. elegans.

Dr. Culotti and his team were the first to identify a neuron guidance cue in these worms – called UNC-6/Netrin – which gives information to growing neurons, in essence telling their axons them in which direction to grow. To work properly, neurons have to develop the right connections to other neurons. UNC-6 acts like a road sign that points some neurons in one direction and others in a different direction. His lab has also identified five new genes that are involved in axon guidance which are being characterized in molecular detail.