Mount Sinai Hospital
Joseph & Wolf Lebovic Health Complex
600 University Ave
Toronto Ontario M5G 1X5
Dr. Anthony (Tony) Pawson
Tony Pawson revolutionized our understanding of the way our cells work
in health and in disease. His discoveries contribute to every aspect of
medical research and have relevance for the understanding and treatment
of a host of diseases including cancer, diabetes, and disorders of the
immune system. In the 25 years he spent studying how cells grow and
communicate with each other, he became a world leader and one of the
top 25 cited scientists in his field.
particular, Dr. Pawson studied signal transduction, in other words, the
way in which cells control their own and each other's behaviour through
chemical signals. Many disease processes such as diabetes, heart
disease, autoimmunity and cancer arise from defects in signaling.
Modern drug development therefore, is based on understanding and
intervening in this process. In cancer for example, an aberrant signal
causes cells to grow in an uncontrolled fashion. Dr. Pawson's
groundbreaking discoveries related to signal transduction allowed for
the development of a new generation of drugs that halt the
proliferation of some kinds of cancer cells.
Pawson was a Distinguished Scientist and Apotex Chair in Molecular
Oncology at the Lunenfeld-Tanenbaum Research Institute of Mount Sinai
Hospital and a Senior Fellow, Massey College, University of Toronto. In
June 2008, he was the first Canadian scientist to be named a Kyoto
Prize Laureate. In 2006, he was inducted into the Canadian Medical Hall
of Fame, and that same year he was named to the Order of the Companions
of Honour by Her Majesty Queen Elizabeth II, one of only nine Canadians
to have received such an honour. He has received international
recognition for his research achievements and his list of prestigious
awards and honours includes the 2007 Premier's Summit Award for Medical
Research, the Gairdner Foundation International Award, the Dr. H.P.
Heineken Prize for Biochemistry and Biophysics (Netherlands), the
Louisa Gross Horwitz Prize (Columbia University) and the Wolf Prize in
Medicine (Israel). He was elected to the Order of Ontario, and to the
Royal Society of London and the Royal Society of Canada. He authored
more than 370 scholarly publications.