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Dr. George Fantus
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Dr. George Fantus

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Dr. George Fantus
ASSOCIATE MEMBER


Dr. Fantus is currently an Associate Member at the  Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, as well as a Senior Scientist at the Toronto General Hospital Research Institute and Director of the Core Laboratory of the Banting and Best Diabetes Centre at the University of Toronto.

His clinical work in endocrinology and on Type 2 diabetes is located at the Mount Sinai Hospital/University Health Network, Division of Endocrinology and Metabolism. 

In his lab, Dr. Fantus uses cultured cells and mouse models to investigate the molecular mechanism of insulin resistance and the toxic effects of high glucose that accompany diabetes. He is looking into the role of various kinases, phosphatases and signaling pathways that are responsible for sensitizing cells to the effects of insulin.

 
Lunenfeld-Tanenbaum Research Institute
871-600 University Avenue
Toronto ON M5G 1X5

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At a Glance

  • Dr. Fantus' lab aims to determine the mechanisms behind insulin resistance toward new treatments and methods to prevent insulin resistance.

  • His research interests include the mechanism of insulin signal transduction, with a specific focus on insulin resistance and Type 2 diabetes. 

  • Dr. Fantus also investigates various molecular complications involved in diabetes, specifically diabetic nephropathy.

  • In 1993, he received the Young Scientist Award from the Canadian Diabetes Association, and he has published over 100 articles.

  

Major Research Activities

Dr. Fantus has discovered ways by which abnormal glucose metabolism due to hyperglycemia can alter gene expression. Studies are carried out in insulin-resistant target tissues, adipocytes and muscle cells to determine changes in enzyme activation, protein-protein interactions and glucose transport.

Dr. Fantus' lab also undertakes investigations to define the pathogenesis of diabetic nephropathy. His work on this includes studying the effects of high glucose on cell signaling, oxidative stress, excess O-glycosylation and abnormal gene expression.

 

Recent Publications

 

Document Actions
Ontario Health Study Faculty of Medicine, University of Toronto. mitacs honorary partner

 

 
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