Dr. Sean Cleary — The Samuel Lunenfeld Research Institute

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Dr. Sean Cleary
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Dr. Sean Cleary is a clinician-scientist at Mount Sinai Hospital and the University Health Network. His research interests are focused on the genetic epidemiology of liver, pancreas and colorectal cancer, and his clinical practice is in the surgical management of these malignancies.

Dr. Cleary is focused on exploring how the risk of developing cancer is influenced by our genetic makeup as well as the environment around us. Individual genetic variants, either alone or in combination with other variants, can contribute small incremental changes to our cancer risk. Genetic factors can also influence our susceptibility to environmental factors that either increase, or decrease, our risk of cancer. Dr. Cleary is working to understand the relationship between genetic variation and environmental exposures, to help identify high-risk groups in our population and provide insight into the etiologic mechanisms of cancer.

Samuel Lunenfeld
Research Institute
Mount Sinai Hospital
Joseph and Wolf Lebovic Health Complex
60 Murray St, Box 42
Toronto ON M5T 3L9

Tel.: 416-586-4800

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Jun 07, 2011 04:20 PM

At a Glance

Dr. Sean Cleary is a clinician-scientist focused on the genetic epidemiology of liver, pancreas and colorectal cancer, as well as the surgical treatment of these malignancies.
He completed a fellowship in Pancreatic and Hepatobiliary Surgical Oncology and Transplantation at the Toronto General Hospital after finishing his General Surgery Residency training at the University of Toronto.
During his residency, Dr. Cleary obtained a Master’s of Science in Cancer Genetics under the supervision of Dr. Steven Gallinger, and completed a MHSc in Public Health and Epidemiology in the Department of Public Health Sciences.

Major Research Activities

Dr. Cleary’s research to date has included characterization of the colorectal cancer risk associated with variants in the APC and Blm genes. In collaboration with the Colon Family Registry, he studied the association between mutations in the MUYH gene and colorectal cancer. His recent work has also included studying the associations between variants in carcinogen metabolism genes and smoking in colorectal and pancreatic cancer.

Recent Publications

Cleary SP, Zhang W, Di Nicola N, Aronson M, Aube J, et al. Heterozygosity for the BLM(Ash) mutation and cancer risk. Cancer Res. 2003 Apr 15;63(8):1769-71

Croitoru ME, Cleary SP, Di Nicola N, Manno M, Selander T, et al. Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk. J Natl Cancer Inst. 2004 Nov 3;96(21):1631-4.

Jenkins MA, Croitoru ME, Cleary SP, Cotterchio M, Hopper JL, Gallinger S Risk of Colorectal Cancer in Monoallelic and Biallelic carriers of MYH mutations: a Population-based case-family. Cancer Epidemiol. Biomarkers Prev 2006; 15(2): 312-314

Croitoru ME, Cleary SP, Berk T, DiNicola N, Kopolovic I, et al. Germline MYH mutations in a clinic-based series of Canadian multiple colorectal adenoma patients. J Surg Oncol 2007; 95(6): 499-506.

O’Shea AM, Cleary SP, Croitoru MA, Kim H, Berk T, et al. Pathologic Features of Colorectal Carcinomas in MYH-associated polyposis. Histopathology. 2008; 53(2): 184-194.

Ali M, Kim H, Cleary SP, Cupples C, Gallinger S, Bristow R. Characterization of mutant MUTYH proteins associated with familial colorectal cancer. Gastroenterology. 2008; 135(2): 499-507.

Cleary SP, Kim H, Croitoru ME, Knight JA, Gallinger S, Gryfe R. Missense Polymorphisms in the Adenomatous Polyposis Coli Gene and Colorectal Cancer Risk. Dis Colon Rectum.2008; 51(10): 371-82

Cleary SP, Cotterchio M, Kim H, Jenkins MA, Bristow R, et al. Germline MYH mutations and Colorectal Cancer: a Multi-site, Population-based Case-control study. Gastroenterology. 2009; 136: 1251-1260.

Cleary SP, Cotterchio M, Shih E, Gallinger S, Harper P. Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes and colorectal cancer risk. American Journal of Epidemiology. 2010; 17(9): 1000-14.

Theodoratou E, Campbell H, Tenesa A, Houlston R,Webb E, Gallinger S, Cleary SP, et al. A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants. British Journal of Cancer. 2010; 103(12): 1875-84

Win AK, Cleary SP, Dowty J, Lindor NM, Newcomb PA, et al. Cancer risks of cancers for monoallelic MUTYH carriers with a family history of colorectal cancer. International Journal of Cancer. 2010.

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