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Dr. Gary Bader
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Dr. Gary D. Bader

ASSOCIATE MEMBER

Dr. Gary D. Bader is an Associate Member at the Lunenfeld. He works on biological network analysis and pathway information resources as an Assistant Professor at the Terrence Donnelly Centre for Cellular and Biomolecular Research (CCBR) at the University of Toronto. He recently completed post-doctoral work in the group of Chris Sander in the Computational Biology Center (cBio) at Memorial Sloan-Kettering Cancer Center in New York.
Dr. Bader developed the Biomolecular Interaction Network Database (BIND) during his Ph.D. in the lab of Christopher Hogue in the Department of Biochemistry at the University of Toronto and the Samuel Lunenfeld Research Institute at Mount Sinai Hospital in Toronto. He completed a B.Sc. in Biochemistry at McGill University in Montreal.

 
 
Samuel Lunenfeld Research Institute
Joseph & Wolf Lebovic Health Complex
600 University Avenue
Toronto Ontario M5G 1X5
t 416-978-3935
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 Lab Website

 
Aug 12, 2009 10:30 AM

     

At a Glance

  • The Bader lab looks at predicting biological interactions

  • The Bader lab aims to predict biological interactions in cells from genomic data and to better understand cellular systems and pathways

 

 

Major Research Activities

The Bader lab aims to develop a computational cell map that organizes all biological processes and their component interactions and molecules. This map can then be read to understand how biological processes work, what the function of a gene is, and what effects disease-associated or engineered mutations have. Cell maps from different organisms or cell types can be compared to identify important components. Three research tracks and one software infrastructure track are actively developing to reach this goal. 

 

 

Recent Publications

Positive Selection of Tyrosine Loss in Metazoan Evolution.Tan CS, Pasculescu A, Lim WA, Pawson T, Bader GD, Linding R. Science. 2009 Jul 9.

Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases.Chris Soon Heng Tan, Bernd Bodenmiller, Adrian Pasculescu, Marko Jovanovic, Michael O. Hengartner, Claus Jørgensen, Gary D. Bader, Ruedi Aebersold, Tony Pawson, and Rune Linding
Science Signaling 2(81):r39 (2009)

A Specificity Map for the PDZ Domain Family.
Raffi Tonikian, Yingnan Zhang, Stephen L. Sazinsky, Bridget Currell, Jung-Hua Yeh, Boris Reva, Heike A. Held, Brent A. Appleton, Marie Evangelista, Yan Wu, Xiaofeng Xin, Andrew C. Chan, Somasekar Seshagiri, Laurence A. Lasky, Chris Sander, Charles Boone, Gary D. Bader, Sachdev S. Sidhu PLoS Biology Vol. 6, No. 9, e239

 

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